Puiphai started her career, working in Singapore at the award-winning firm – WOHA, where she became Associate in 2006, and co-founded WOHA (Thailand) in 2008. At present, she is the founder and Managing Director of Creative Crews Ltd. As Project Director, she is in charge of projects ranging from high rise and low rise housing projects, commercial mixed developments such as offices and hotels, to institutional projects such as libraries and museums.

Her projects has been recognized by international publications and award organizations, for instance Siamese Gioia condominium received the Citation Award from the Association of Siamese Architects, and Siamese Ratchakru condominium was shortlisted for Best Tall Building Awards organized by CTBUH (Council on Tall Building and Urban Habitat).

Apart from practicing, Puiphai also serves as a judge in several architectural competitions, gives lectures, and guest critique at various architectural schools and universities, around the globe such as Chulalongkorn University in Bangkok, Thailand and Graz University of Technology in Styria, Austria.